Atrial fibrillation (AF) is the most common observed arrhythmia in clinical practice.In the literature, AF events associated with drug induction bar drain board are available.Cetirizine is a second-generation histamine antagonist used in the treatment of allergies, angioedema, and urticaria.We wish to iphone 13 pro max price florida present an atypical case who took cetirizine medication for relieving symptoms of upper tract respiratory system infection, experienced rapid ventricular response AF and treated successfully.To best of our knowledge, this is the first case of cetirizine-induced AF.